Top Supplements to Support and Detoxify the Liver

These supplements are supported by scientific research for their hepatoprotective (liver-protecting) properties:

✅ 1. Milk Thistle (Silybum marianum)
Active compound: Silymarin

Benefits: Antioxidant, anti-inflammatory, and promotes liver cell regeneration.

Evidence: Strong evidence for use in liver diseases such as hepatitis and fatty liver.

Dosage: 150–300 mg standardized extract (70–80% silymarin), 2–3 times daily.

✅ 2. N-Acetyl Cysteine (NAC)
Role: Precursor to glutathione, a powerful antioxidant in the liver.

Benefits: Protects against oxidative stress and toxins (e.g., acetaminophen damage).

Dosage: 600–1,200 mg daily.

Caution: Should not be taken without medical supervision if you have asthma or take nitroglycerin.

✅ 3. Alpha-Lipoic Acid (ALA)
Function: Regenerates other antioxidants like glutathione and vitamin C.

Benefits: Reduces liver inflammation and may help in non-alcoholic fatty liver disease (NAFLD).

Dosage: 300–600 mg daily.

✅ 4. Turmeric (Curcumin)
Properties: Anti-inflammatory, antioxidant.

Benefits: Protects liver cells from damage and may improve liver enzymes in NAFLD.

Dosage: 500–1,000 mg/day (standardized to 95% curcuminoids with black pepper for absorption).

✅ 5. Dandelion Root
Uses: Traditionally used to promote bile flow and reduce liver congestion.

Benefits: Mild diuretic and liver tonic effects.

Dosage: 500–1,000 mg extract, or as a tea.

✅ 6. Artichoke Leaf Extract
Function: Increases bile production, improves digestion, and may protect liver cells.

Benefits: May help lower liver enzyme levels.

Dosage: 300–640 mg extract per day.

✅ 7. Schisandra Berry
Traditional Use: Chinese medicine adaptogen that supports liver function.

Benefits: Enhances liver enzyme activity and detox pathways.

Dosage: 500–1,000 mg extract daily.